منابع مشابه
Presynaptic active zones in invertebrates and vertebrates.
The regulated release of neurotransmitter occurs via the fusion of synaptic vesicles (SVs) at specialized regions of the presynaptic membrane called active zones (AZs). These regions are defined by a cytoskeletal matrix assembled at AZs (CAZ), which functions to direct SVs toward docking and fusion sites and supports their maturation into the readily releasable pool. In addition, CAZ proteins l...
متن کاملWhere does metonymy stop? Senses, facets and active zones
Within the framework of Cognitive Linguistics both metonymy and metaphor are seen as pervasive phenomena in thought and language. They are, however, different conceptualizations of experience. Metaphorization, such as ‘Love is a journey’, involves the mapping between a source and a target in different ontological domains. Metaphorization is based on a relation of configurational sameness (PATH)...
متن کاملClathrin-mediated endocytosis near active zones in snake motor boutons.
We have used the activity-dependent probe FM1-43 with electron microscopy (EM) to examine endocytosis at the vertebrate nerve-muscle synapse. Preparations were fixed after very brief neural stimulation at reduced temperature, and internalized FM1-43 was photoconverted into an electron-dense reaction product. To locate the reaction product, we reconstructed computer renderings of individual term...
متن کاملRab3 Dynamically Controls Protein Composition at Active Zones
Synaptic transmission requires the localization of presynaptic release machinery to active zones. Mechanisms regulating the abundance of such synaptic proteins at individual release sites are likely determinants of site-specific synaptic efficacy. We now identify a role for the small GTPase Rab3 in regulating the distribution of presynaptic components to active zones. At Drosophila rab3 mutant ...
متن کاملActive Zones on Motor Nerve Terminals Contain a3b1 Integrin
Active zones are the sites along nerve terminals where synaptic vesicles dock and undergo calcium-dependent exocytosis during synaptic transmission. Here we show, by immunofluorescent staining with antibodies generated against Xenopus laevis integrins, that a3b1 integrin is concentrated at the active zones of Xenopus motor nerve terminals. Because integrins can link extracellular matrix molecul...
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ژورنال
عنوان ژورنال: Annual Meeting of the Berkeley Linguistics Society
سال: 1984
ISSN: 2377-1666,0363-2946
DOI: 10.3765/bls.v10i0.3175